Shubham Maurya, Ph.D.

Achievements and Contributions

Google Scholar Profile
Pubmed Articles
CV

Articles from Postdoc

  1. Kumar M, Karnam S, Maurya S, Nagireddy R, Flanagan JG , Gronert K . Lipoxin B4 Mitigates TRPV4-Activated Müller Cell Gliosis During Ocular Hypertension. bioRxiv 2025.
  2. Mathew DJ , Maurya S, Ho J , I Livne-Bar, Chan D, Buys Y, Sit M, Trope G, Flanagan JG, Gronert K, Sivak JM. Lipidomic Analysis Reveals Drug-Induced Lipoxins in Glaucoma Treatment. bioRxiv 2025.
  3. Maurya S, Lin M, Karnam S, Singh T, Kumar M, Ward E, Sivak J, Flanagan JG, Gronert K. Regulation of Disease-Associated Microglia in the Optic Nerve by Lipoxin B4 and Ocular Hypertension. Mol Neurodegeneration. 2024;19,86.
  4. Karnam S, Maurya S, Ng E, Choudhary A, Thobani A, Flanagan JG, Gronert K. Dysregulation of Neuroprotective Lipoxin Pathway in Astrocytes in Response to Cytokines and Ocular Hypertension. Acta Neuropathol Commun. 2024; 12: 58.
  5. Livine-Bar I, Maurya S, Gronert K, Sivak JM. Lipoxins A4 and B4 Inhibit Glial Cell Activation Via CXCR3 Signaling in Acute Retinal Neuroinflammation. J Neuroinflammation. 2024. 2024;21(1):18.

Articles from Ph.D.

  1. Maurya S, Sarangi P, Jayandharan GR. Safety of Adeno-associated virus-based vector-mediated gene therapy—impact of vector dose. Cancer Gene Ther. 2022; 29: 1305-1306.
  2. Maurya S, Jayandharan GR*. Gene Therapy: Contest between Adeno-associated virus and host cells and the impact of UFMylation. Mol Pharm. 2020; 10: 3649-3653.
  3. Maurya S, Jayandharan GR. Exosome-associated SUMOylation mutant AAV demonstrates improved ocular gene transfer efficiency in vivo. Virus Res. 2020; 283: 197966.
  4. Maurya S, Mary B, Jayandharan GR. Improved ocular gene transfer with a Neddylation-site modified AAV-RPE65 vector in rd12 mice. Eye. 2020; 34: 1313-1315.
  5. Mary B*, Maurya S*, Arumugam S, Kumar V, Jayandharan GR. Post-translational modifications in capsid proteins of recombinant Adeno-associated virus (AAV) 1-Rh10 serotypes. FEBS J. 2019; 286: 4964–4981. *equal contribution
  6. Maurya S, Mary B, Jayandharan GR. Rational engineering and preclinical evaluation of Neddylation and SUMOylation site modified adeno-associated virus vectors in murine models of hemophilia B and Leber congenital amaurosis. Hum Gene Ther. 2019; 30: 1461-1476.
  7. Mary B, Maurya S, Kumar M, Bammidi S, Kumar V, Jayandharan GR. Molecular Engineering of Adeno-Associated Virus Capsid Improves Its Therapeutic Gene Transfer in Murine Models of Hemophilia and Retinal Degeneration. Mol. Pharm. 2019; 16: 4738-4750.
  8. Khan N, Maurya S, Bammidi S, Jayandharan GR. AAV6 vexosomes mediate robust suicide gene delivery in a murine model of hepatocellular carcinoma. Mol Ther-Meth Clin D. 2020;17: 497-504.

Conferences

  1. (Talk) Maurya S, Kumar M, Bajoua B, Liu YX, Sharma P, Han J, Choudhary A, Adcook S, Karnam S, Flanagan JG, Gronert K. Macroglia-specific 15-Lipoxygenase Regulates OHT-induced Neurodegeneration and Microglia-mediated Neuroinflammation in the Optic Nerve. The Association for Research in Vision and Ophthalmology meeting, Salt Lake City, UT, 2025.
  2. (Poster) Karnam S, Yan A, Maurya S, Adcook S, Kumar M, Gronert K, Flanagan JG. Lipoxin B4 Reverses Astrocyte-Derived Complement C3 Activation and Neuroinflammation in Ocular Hypertension. The Association for Research in Vision and Ophthalmology meeting, Salt Lake City, UT, 2025.
  3. (Poster) Kumar M, Karnam S, Maurya S, Flanagan JG, Gronert K. Lipoxin B4 Mitigates TRPV4 Activated Müller Cell Gliosis During Ocular Hypertension. The Association for Research in Vision and Ophthalmology meeting, Salt Lake City, UT, 2025.
  4. (Talk) Maurya S, Lin M, Karnam S, Singh T, Kumar M, Ward E, Flanagan JG, Gronert K. Lipoxin B4 Regulates Disease-Associated Microglia in the Myelinated Optic Nerve During Ocular Hypertension. The Association for Research in Vision and Ophthalmology meeting, Seattle, WA, 2024.
  5. (Talk) Lin M, Maurya S, J Kim S, Flanagan JG, Gronert K. 5-lipoxygenase Regulates Optic Nerve Microglial Phenotype and Homeostatic Function During Ocular Hypertension Insult. The Association for Research in Vision and Ophthalmology meeting, Seattle, WA, 2024.
  6. (Talk) Karnam S, Maurya S, Duda M, Liu YX , Ward E, Kumar M, Singh T, Gronert K, Flanagan JG. Inhibition of Constitutive Retinal Prostaglandin D2 by a Topical NSAID Amplifies Neurodegeneration in Response to Ocular Hypertension. The Association for Research in Vision and Ophthalmology meeting, Seattle, WA, 2024.
  7. (Poster) Kumar M, Karnam S, Maurya S, Flanagan JG, Gronert K. Lipoxin B4 Regulates Muller Glia Reactivity: Understanding the Lipoxin Pathway in Muller Glia. The Association for Research in Vision and Ophthalmology meeting, Seattle, WA, 2024.
  8. (Poster) Ward E,  Karnam S, Duda M,  Maurya S, Kumar M, Gronert K, Flanagan JG. Ocular hypertension-induced neurodegeneration is associated with upregulation of Prostaglandin E2 receptor EP1 in the retina. The Association for Research in Vision and Ophthalmology meeting, Seattle, WA, 2024.
  9. (Poster) Gronert K, Karnam S, Ward E, Kumar M, Duda M, Thobani A, Maurya S, Ho J, Flanagan JG. Lipoxin B4 Regulates Pro-Survival Kinase Signaling in the Mouse Retina and Human Astrocytes. The Association for Research in Vision and Ophthalmology meeting, Seattle, WA, 2024.
  10. (Poster) Maurya S, Karnam S, Lin M, Kumar M, Singh T, Ng E, Flanagan JG, Gronert K. LXB4 regulates optic nerve microglia phenotype and function in ocular hypertension neuropathy. The Association for Research in Vision and Ophthalmology meeting, New Orleans, LA, 2023.
  11. (Talk) Karnam S, Maurya S,  Thobani A,  Choudhary A,  Gronert K,  Flanagan JG. LXB4 Treatment Reduces Astrocyte Reactivity in Response to Cytokines and Ocular Hypertension. The Association for Research in Vision and Ophthalmology meeting, New Orleans, LA, 2023.
  12. (Poster) Kumar M, Karnam S, Maurya S, Singh T, Flanagan JG, Gronert K. Muller Glia’s Role in the Neuroprotective Lipoxin Pathway in the Retina. The Association for Research in Vision and Ophthalmology meeting, New Orleans, LA, 2023.
  13. (Poster) Flanagan JG, Gronert K, Maurya S, Ng E, Karnam S. Lipoxin Formation is a Neuroprotective Function in the Retina, Optic Nerve and Brain of Rodents and Primate Astrocyte. The Association for Research in Vision and Ophthalmology meeting, New Orleans, LA, 2023.
  14. (Poster) Maurya S, Karnam S, Yang L, Flanagan JG, Gronert K. LXB4 regulation of microglia responses in ocular hypertension induced neuropathy. The Association for Research in Vision and Ophthalmology meeting, Denver, CO, 2022.
  15. (Poster) Karnam S, Maurya S, Ng E, Yang L, Wang E, Gronert K, Flanagan JG. Dysregulation of Neuroprotective Lipoxin Pathways in the Mouse Retina Following Silicon Oil-Induced Ocular Hypertension. The Association for Research in Vision and Ophthalmology meeting, Denver, CO, 2022.
  16. (Talk) Maurya S, Mary B, Jayandharan GR. Neddylation and SUMOylation Site Modified Adeno- associated Virus Vectors Demonstrate Enhanced Hepatic Factor IX Gene Delivery In vivo. XXVII Congress of the International Society of Thrombosis and Hemostasis and 65th Annual Scientific and Standardization committee (SSC) meeting, Melbourne, 2019.
  17. (Poster) Maurya S, Mary B, Jayandharan GR. Ocular gene therapy with a synthetically engineered AAV enhances visual function in a pre-clinical model of Leber congenital amaurosis, European Society for Gene and Cell Therapy meeting, Barcelona, 2019.
  18. (Poster) Mary B, Maurya S, Jayandharan GR. Modulation of glycosylation status of Adeno-associated virus (AAV) vectors improves its hepatic and ocular gene transfer in vivo, American Society for Gene and Cell Therapy meeting, Washington DC, 2019.

Invited Talks

  1. Unfolding the Actions of Small Lipid Mediators for Neuroprotection in Glaucoma, Herbert Wertheim School of Optometry and Vision Science, UC Berkeley. OXYOPIA Seminar 2025.
  2. Defining Microglia Homeostatic and Functional Phenotypes in Glaucomatous Injuries: Beyond Single-Cell Transcriptomics. Vice President Session: Next-gen researchers in ocular immunology. Minisymposium. ARVO 2024.
  3. Regulation of homeostatic and disease-associated microglia phenotypes in the optic nerve by LXB4: A potential target for neuroprotection. New therapeutic targets for retinal ganglion cell neuroprotection. XXVI Biennial Meeting of the International Society for Eye Research 2024.

Awards

  1. NIH[NEI] K99/R00 Pathway to Independence Award 2025.
  2. Travel Award, ISER BrightFocus Glaucoma Symposium, Atlanta, 2025.
  3. Travel Award, XXVI Biennial Meeting of the International Society for Eye Research in Buenos Aires, Argentina 2024.
  4. Early Career Researcher Editorial Board Member for The FASEB Journal (2024-2025). 
  5. BrightFocus Foundation National Glaucoma Research Award 2023.
  6. The Thomas R. Lee Award for National Glaucoma Research 2023.
  7. ARVO Science Communication Training Fellowship 2023.
  8. Reach the world fellowship, XXVII Congress of the International Society of Thrombosis and Hemostasis and 65th Annual Scientific and Standardization Committee (SSC) Meeting, 2019 Melbourne, Australia.

Patents

  1. A process for producing a plurality of neddylation site-modified AAV vectors. Rao JG, Maurya S, US Patent App. 17/294,222.
  2. A process for producing a plurality of sumoylation target-site modified AAV vector and product thereof. Rao JG, Maurya S. US Patent App. 17/293,164. Licensed to Laurus Labs, India.
  3. SUMOylation target-site modified AAV vector, methods and sequence for gene therapy- Indian Patent 505372; International: PCT/IB2019/058630; Maurya S, Jayandharan GR. Licensed to Laurus Labs, India.
  4. Process for modifying neddylation site of an AAV vector and product there of- Indian Patent 404488; International: PCT/IB2019/057036. Maurya S, Jayandharan GR. Licensed to Reliance Life Sciences, India.
  5. Recombinant adeno-associated vectors and method thereof. Indian Patent 547513. Maurya S, Mary B, Jayandharan GR. Licensed to Laurus Labs, India.

Professional Memberships

  1. 2024- Present: International Society for Eye Research (ISER)
  2. 2022- Present: The Association for Research in Vision and Ophthalmology (ARVO)